| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
20권 2호 |
| 발표분야 |
생물공학_포스터 |
| 제목 |
Delivery of Diagnostic and Therapeutic Radioisotopes to the Prostate Cancer using DOTA Chelator-Conjugated Peptides |
| 초록 |
Radiation therapy which utilizes radiation to induce cell death is an effective cancer therapeutic option in conjunction with chemotherapy and surgery. In particular, tumor cell-targeting peptides have been successfully used in peptide receptor radionuclide therapy (PRRT). PRRT is a tumor-directed systemic treatment, and 68Ga/177Lu-octreatate for the treatment of neuroendocrine tumor has shown the therapeutic effect of PRRT. In this study, a series of DOTA chelator-conjugated peptides were synthesized, and radiolabeled with 68Ga and 177Lu. The pharmacokinetic characteristics, imaging diagnosis and therapeutic efficacy of the radiolabeled peptides were investigated using PC-3 human prostate carcinoma xenograft model in vivo. |
| 저자 |
임재청, 조은하, 이소영, 도소희, 김수용, 정성희
|
| 소속 |
한국원자력(연) |
| 키워드 |
PRRT / Radioisotope / Prostate cancer / Peptide |
| E-Mail |
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