| 초록 |
Various inorganic ion-releasing hydrogels have been developed to facilitate tissue regeneration. Recently, zinc ions (Zn2+) have attracted much attention as a signaling molecule that plays a critical role in the wound healing process and tissue regeneration. While various Zn2+-releasing hydrogels have been reported, nobody utilized zinc peroxide (ZnO2) as a crosslinker to prepare Zn2+-releasing hydrogels. Herein, we develop Zn2+-releasing gelatin-based hydrogels via ZnO2-mediated crosslinking reaction. The hydrogels release Zn2+ in a sustained manner for up to 14 days. The functional hydrogels show excellent biocompatibility in vitro and in vivo. Interestingly, we demonstrate that the hydrogels facilitate cell proliferation, vascular recruitment, hair follicle development, and collagen synthesis. In sum, we suggest that our Zn2+-releasing hydrogels hold great potential as wound healing materials for advanced wound management and tissue regeneration. |
