| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Multistage Drug Delivery through Gelatin Nanoparticles with pH-Sensitive Dendrimer for Deep Tissue Penetration |
| 초록 |
A multistage drug delivery system for cancer therapy can be controlled by microenvironment such as high concentrations of matrix metalloproteinase (MMPs), low pH condition. In this research, an anticancer drug doxorubicin was covalently conjugated to poly(amidoamine) dendrimer by hydrazone bond(PAMAM-hyd-DOX) for pH-sensitive releasing in the tumor site. Gelatin nanoparticles encapsulating PAMAM-hyd-DOX was crosslinked by benzoic imine bond which can be ruptured in mildly acid condition. The system has an initial larger size for enhanced permeability and retention effect and can be reorganized into smaller nanoparticles in tumor microenvironment by hydrolysis of benzoic imine bond and MMP-2 sensitive shrinkage. The smaller nanoparticles can induce deep tissue penetration and efficient cellular uptake. Then, PAMAM-hyd-DOX released doxorubicin in intracellular tumor site by pH-triggered cleavage of the hydrazone bond. The system is effective to reduce side effects of doxorubicin. |
| 저자 |
박소연1, 안철희2
|
| 소속 |
1Research Institute of Advanced Materials (RIAM), 2Department of Materials Science and Engineering |
| 키워드 |
pH senstive; multistage; drug delivery system; doxorubicin; cancer therapy
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| E-Mail |
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