| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Synthesis and characterization of bioreducible PEG-PBLA2 miktoarm copolymer for anticancer drug delivery |
| 초록 |
Self-assembled nanoparticles from amphiphilic copolymers have shown excellent performance as nanocarrier for drug delivery. Recently, new classes of star-shaped polymers where any number of various types of polymer arms emanate from a core, so-called miktoarm polymers, have attracted much attention for self-assembling nano-structure formation and their potential applications in drug delivery. In particular, amphiphilic AB2 miktoarm copolymers that mimic structural characteristics of phospholipid, have a unique self-assembling properties in aqueous media. In this study, we synthesized a bioreducible PEG-PBLA2 miktoarm copolymers consisting of hydrophilic poly(ethylene glycol) block and hydrophobic poly(β-benzyl L-aspartate) block and their self-assembling and bioreducible properties were observed for drug delivery application. |
| 저자 |
이영주1, 서진솔1, 김유경1, 이립1, 이은지1, 강한창2, 허강무1
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| 소속 |
1충남대, 2가톨릭대 |
| 키워드 |
miktoarm polymer; PEG; PBLA; nanoparticle; self-assembly; bioreducible polymer
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| E-Mail |
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