| 초록 |
Long-term survival of cancer patients treated with conventional therapies still remains poor, and, thus, the need for novel approaches is raised. Gene delivery may provide a means of treatment for a wide range of cancers. Up to the present, several viral vectors have been used for gene delivery, because they have high affinity and can be efficiently transfected into the cells. However, the degree of toxicity and immune response against repeated administration limit their practical application, in addition to the fact that viral vectors are difficult to produce on a large scale. Non-viral vectors, on the other hand, have some advantages compared to the viral vectors in that they are easier to use and invoke less of an immune response. Moreover, they can also deliver high molecular weight DNA molecules. Several studies have demonstrated that binding of DNA with cationic polymers may be useful for gene delivery both in vivo and in vitro. We will provide our progress in the development of biocompatible polymers as a non-viral gene delivery carrier because the need to improve the performance of polymer as a gene carrier in terms of binding to cell surface, endocytosis, escape from endosomal lysosomal network, translocation to the cell nucleus, and vector-unpacking is imperative. Towards this end, we will propose some of biocompatible gene carriers, which are expected to have low toxicity with high efficiency in tumor cells. Supported by the grant from KOSEF. |
