| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Synthesis and characterization of bioreducible poly(ethylene glycol)-poly(β-benzyl-L-aspartate) AB2 miktoarm copolymers for drug delivery system |
| 초록 |
In recent studies, new classes of star-shaped polymers where any number of various types of polymer arms emanate from a core, miktoarm polymers, have attracted much attention for their potential applications in drug delivery system. In this study, we synthesized a bioreducible PEG-PBLA2 miktoarm copolymers consisting of hydrophilic poly(ethylene glycol) block and hydrophobic poly(β-benzyl L-aspartate) block were worked through the ring-opening polymerization of β-benzyl-L-aspartate N-carboxyanhydride using a PEG macroinitiator. We have observed the self-assembly behavior, drug-loading capacities, drug release and bioreducible features of the PEG-PBLA2 copolymers. The PEG-PBLA2 copolymers can easily form a spherical micelle structure in aqueous media. For drug-loading and release study, we used doxorubicin and it form a self-assembled NPs after loaded with PEG-PBLA2. We have also observed the anti-cancer effects of Dox-loaded PEG-PBLA2 copolymers via MTT assay using KB cells. |
| 저자 |
이영주1, zehedian khatun1, 서진솔1, 김유경1, 이립1, 이은지1, 강한창2, 허강무1
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| 소속 |
1충남대, 2카톨릭대 |
| 키워드 |
miktoarm copolymer; PEG; PBLA; micelles; bioreducible
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| E-Mail |
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