화학공학소재연구정보센터
학회 한국화학공학회
학술대회 2011년 봄 (04/27 ~ 04/29, 창원컨벤션센터)
권호 17권 1호, p.31
발표분야 고분자
제목 Membrane properties of polymer-lipid hybridsome using amphiphilic poly(asparagines)
초록 We prepared polymer-lipid hybridsomes of saturated lecithinwith poly(asparagines) grafted with alkyl chains (PAsn-Cn).The inclusion of polymer lowered the membrane rigidity of polymer hybridized liposome (PHL). Membrane fluidity of PHL using PAsn-C18 and PAsn-C22 decreased by the increaseofpolymer concentrationdue to the tighter packing of lipid components. The membrane rigidiity of vesicles increasedby increasing the alkyl chain length at the same polymer concentration.DSC results confirmed that the amphipilic polymers (PAsn-Cn) were incorporated well with PC liposomes without making the separated polymer aggregates. The polymer-lipid mixed micelles were expected to form more by increase of polymer concentration which grafted with long alkyl chains. PAsn-C8 was expected to form polymer-lipid mixed micelles easily even at a low polymer concentration due to its high hydrophilicity.The phase transition temperature of liposome was changedbythe inclusion of amphilphilic polymers,and it wasaffectedby thepolymer concentrationandalkyl chain lengthof polymer.
저자 박성일1, 김종득2
소속 1아모레퍼시픽 기술(연), 2한국과학기술원 생명화학공학과
키워드 poly(asparagine); liposome
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