| 초록 |
Natural killer (NK) cells have been recognized as the next generation therapy of cancer treatments because they are less likely to trigger side than T cell-based treatments. Here, we developed an efficient method of activating NK cells using charged nanoparticles (cNPs). In vitro cytotoxic activity of cNP-treated NK cells against breast cancer cells was two-fold higher than that of naive NK cells. Molecular biological analyses confirmed that cNPs induced the expression of chemokine receptors of NK cells. In vitro live cell imaging exhibited that cNP treated NK cells were better than control NK cells at interacting with cancer cells. Consistent with results, cNP-treated NK cells demonstrated an excellent anti-tumor effect in tumor animal models. Besides, cNP treated NK cells were effectively tracked by MRI in vivo. Taken all together, cNP-mediated activation of NK cells has great potential as immune cell-based cancer immunotherapy. |
