| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Hypoxia targeting Smart Nanoconstructs with Dual photothermal cancer therapy and T1 MRI imaging |
| 초록 |
Tumor hypoxia is an inadequate supply of oxygen surrounding solid tumors which only integrate cancer cells with therapeutic drug resistance but also facilitate conducive environments for cancer cell proliferation and metastasis. Manganese oxide (MnO2) nanoparticles have been utilized extensively for alternating tumor hypoxia. On contrary, it enhanced generation ofO2 by MnO2 in presence of H2O2 which improve the radiation therapy efficacy and magnetic resonance imaging (MRI) as a T1 contrast agent. Here we present novel hypoxia responsive and simultaneous localized oxygen generating hybrid manganese oxide nanoconstructs (MNCs) to treat cancer. The selective interaction of MNCs with hydrogen peroxide which is vividly present in the cancer cells resulted in reducing the expression of hypoxia inducing factor 1- Alpha (HIF) in the tumor tissues. |
| 저자 |
몬달1, 이용규2
|
| 소속 |
1한국교통대, 2. Department of Green Bio Engineering |
| 키워드 |
tumor Hypoxia; manganese oxide nanoparticles; MRI Imaging
|
| E-Mail |
|
