| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Release and characterization of double-walled microspheres containing water-soluble drugs |
| 초록 | When administering drug into the body, it reveals the decline of drug effect or toxicity. This is due to the concentration of the drug administered in vivo. One method, which is to impregnate drug into polymer matrix, has studied for the control release of drug.1-3 To overcome these problems, double-walled microspheres studied with biodegradable polymers had been investigated. Doxorubicin (DOX), one of the anthracycline ring antibiotics with great antitumor activity against solid tumors and leukemia, has the ability to interact with DNA and consequently inhibit important cellular functions. However, its therapeutic potential has been restricted by its dose-limited cardiotoxicity and by the resistance developed by the tumor cells to this molecule after some time of treatment.4 In this study, We manufactured double-walled microspheres using oil-in-water(O/W) solvent evaporation method with/without ultrasonication to increase the encapsulation ratio of DOX and to control the release of DOX, and to prevent side-effects. Double-walled microsphere is composed of two components; Core consists of the mixture of dextran and DOX and corona consists of PLGA. Double-walled microsphere was characterized by scanning electron microscope (SEM) observation, confocal fluorescence laser microscope observation, and HPLC to measure the release behavior and the encapsulation ratio of DOX. Acknowledgement : This research was supported by Establishment of Nanoscopia Center of Excellence (KMOST) Reference 1. J. C. Cho, D. Yun, G. Khang, J. M. Rhee, Y. S. Kim, J. S. Lee, and H. B. Lee, Biomaterials Research., 4, 136 (2000) 2. J. C. Cho, G. Khang, H. S. Choi, J. M. Rhee, and H. B. Lee, polymer(Korea)., 24, 728 (2000) 3. C. Cho, J. Park, J. Kwon, B. Jo, K. Lee, K. Kim, and Y. K. Sung, polymer(Korea)., 15, 27 (1991) 4. E. C. Tan, R. Lin and C. Wang, J. Colloid and Interface Science, 4, 89 (2005) |
| 저자 | 고종태1, 이재호1, 윤주용1, 박정수1, 육순홍2, 신형식1, 이종문1, 김문석3, 강길선1, 이해방3 |
| 소속 | 1전북대, 2한남대, 3한국화학(연) |
| 키워드 | double-layered spheres; PLGA; Doxorubicin; O/W |
