| 초록 |
The emerging trend in designing advanced hydrogels is to create bioactive hydrogels inducing in situ tissue regeneration via host tissue stimulation by biophysicochemical cues of hydrogels. Among them, hyperoxia (over 21% pO2) has been demonstrated as a crucial signaling parameter in wound healing and tissue regeneration. While various peroxides with catalase have been widely used as oxygen (O2)-generating agents, they still have some limitations, such as excessive oxidative stress and cellular signaling suppression. Herein, we present a catalase-immobilized syringe (Oxyringe) as a new type of O2-supplying system. We fabricate oxygenated hydrogels using Oxyringe, releasing O2 up to hyperoxic levels (47.9% pO2) in vivo. Interestingly, our hydrogels expedite wound healing and tissue regeneration, including hemostasis, inflammation, proliferation, and remodeling phases in vivo. In sum, Oxyringe has excellent potential as an advanced O2-supplying system for in situ tissue regeneration. |
