| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.648 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation of Novel Functional 3MA Bone Cements Containing Biodegradable Materials and Antibiotics |
| 초록 | The main function of bone cement is to stabilize prosthesis by filling the gap between the prosthesis and the surrounding bone and to transmit loads from the prosthesis to the bone. Bis-GMA prepolymer is suitable for use as a binder for reinforcing fillers in bone cement system, since it has relatively low polymerization shrinkage and hardens rapidly under oral conditions when suitably formulated with an appropriate initiator system. We have already prepared a new bioactive bone cement consisting of Bis-GMA derivatives/triethylene glycol dimethacrylate (TEGDMA) resin and apatite and wollastonite-containing glass ceramic (AW-GC) filler. The prepolymer of Bis-GMA derivative, 3MA, has good physical and mechanical properties as compared with Bis-GMA. Meanwhile, a novel drug delivery system containing antibiotics was developed in commercial PMMA bone cement1. In the present study, we have prepared the novel functional 3MA bone cements containing 1) Bis-GMA derivatives (3MA and 3MA mixture) as prepolymer, 2) AW-GC as filler, 3) lactide-based oligomers (GL7-Ac and GL15-Ac) as biodegradable material, and 4) gentamicin sulfate as antibiotics. The resulting functional 3MA bone cements were evaluated by analyzing their physical properties, biodegradable behaviors, and the release of antibiotics. Biodegradable 3MA bone cements containing GL15-Ac 5 wt% indicated that the weight loss was fastest among the tested samples in PBS solution. Fig. 1 shows SEM morphology of biodegradable 3MA bone cements after immersion in stimulated body fluid (SBF) solution. The hydroxyapatite layer was formed in all 3MA bone cement surfaces, especially, GL15-Ac 10% one. In addition, the behaviors of biodegradation and antibiotics release of these functional 3MA bone cements are demonstrated. Fig. 1. SEM morphology of biodegradable 3MA bone cements. Reference 1. D. D. Frazier, V. K. Lathi, T. N. Gerhart, and W. C. Hayes, J. Biomed. Mater. Res., 35, 383 (1997). |
| 저자 | 김재훈1, 안광덕1, 김종만2, 김해중3, 한동근1 |
| 소속 | 1한국과학기술(연), 2한양대, 3(주)메타바이오메드 |
| 키워드 | Bone cement; 3MA prepolymer; Biodegradation; Antibiotics |
