| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
The preparation and evaluation of apigenin nanoparticles for antioxidant |
| 초록 |
One of the flavonoids, apigenin, has a strong antioxidant efficacy. However, it is difficult to develop this material due to its low solubility. The purpose of this study is to increase the solubility by developing apigenin as micelle using biocompatibility polymers, and to evaluate stability, particle size, skin transmittance, and efficacy. Long-term stability was performed by HPLC, particle size was analyzed by ELS, and skin transmittance was performed by Franz diffusion cell for 24 hours. And proceed with an in vitro test(DCF-DA assay). As a result, apigenin nanoparticles were stable for six months, and the particle size was 20 to 80 nm, and the skin transmittance was about 3 %. Antioxidant efficacy was also confirmed by in vitro test. Therefore, the apigenin nanoparticle is expected to be used as antioxidant materials that can be applied to various formulations. This research was carried out with the support of the Ministry of Science and ICT(Project No:2019-DD-RD-0164). |
| 저자 |
박나래1, 조선행2, 안주영3, 김채진4, 구태성1, 이재휘4, 신병철2
|
| 소속 |
1충남대, 2한국화학(연), 3고려대, 4중앙대 |
| 키워드 |
Polymeric micelle; Nanoparticle; Encapsulation; Solubilization
|
| E-Mail |
|
