| 초록 |
Targeting is important in gene delivery system for successful tumor therapy. We prepared targeting peptide nanopaticle with PEG-conjugated chitosan and RGD peptide for gene delivery. RGD peptide(a dimeric RGD peptide, H-Glu[cyclo(Arg-Gly-Asp-D-Phe-Lys)]2) has di-binding moiety able to binding αvβ3 integrin. The polyethylene glycol (PEG) used to linker and hydrophilic site of low molecular weight water soluble chitosan(LMWSC) chain. The physicochemical properties of targeting peptide nanopaticle were analyzed by particle size, 1H-NMR, dynamic light scattering and transmission electron microscope (TEM) measurement. Also, peptide nanopaticle was investigated transfection efficiency. |
