| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Outgrowth endothelial cells-specific capture by antibody immobilization on nano-structured surface |
| 초록 |
Restoration of damaged endothelium might be a well-built way to reduce late stent thrombosis and restenosis. It has been reported that outgrowth endothelial cell (OEC) can differentiate to endothelial cell and then facilitate re-endothelialization. Some groups have developed OECs capture strategy using antibody (Ab) immobilization technologies for the restoration of endothelium. We focused on CD146 as a target surface biomarker for OEC capture. In this study, it is seemed that anti-CD146 Ab-immobilized stent can capture circulating OECs and restore damaged endothelium. Fabrication of silicon nanofilamentwas accomplished for the formation of nano-structured surface. SiNf and anti-CD146 Ab-immobilized surfaces were evaluated by FTIR and contact angle. Anti-CD146 Ab-immobilized surface was evaluated by OEC capture assay. Our results exhibited that anti-CD146 Ab-immobilized surface captured selectively and significantly more OECs than bare surface and anti-CD34 Ab-immobilized surface. |
| 저자 |
강성남, 정윤기, 한동근
|
| 소속 |
한국과학기술(연) |
| 키워드 |
stent; re-endothelialization; OEC; CD146; SiNf
|
| E-Mail |
|
