| 학회 | 한국화학공학회 |
| 학술대회 | 2022년 봄 (04/20 ~ 04/23, 제주국제컨벤션센터) |
| 권호 | 28권 1호, p.1396 |
| 발표분야 | [주제 12] 화학공학일반(부문위원회 발표) |
| 제목 | Fabrication of DNA Aptamer-Organic Phosphor Hybrid Assembly for the Recognition of Tumor Marker |
| 초록 | Fluorescence bio-sensor materials have advantages of high quantum yield, simple processes, and low cost. So, currently commercialized and used. However, the optical overlap between the luminescence of a fluorescent material and the autofluorescence of a biomaterial is a challenge to be solved. In this study, to overcome this limitation, we used a strategy to bypass autofluorescence by using pure organic phosphorescence material. Herein, we used aptamer, the oligonucleotide or peptide molecules that bind to specific target molecules, as a probe to recognize the prostate specific membrane antigen (PSMA). We hybridized with aptamer and organic phosphor to make aptamer-organic phosphor hybrid assembly. The amplification of the phosphorescence intensity and lifetime after target recognition were observed. Furthermore, we confirmed the change in the crystal arrangement of the aptamer-organic phosphor material after recognition of the target. We fabricated an aptamer-pure organic phosphor structure to utilize an autofluorescence detour strategy, and at the same time confirmed the photophysical change through target recognition. |
| 저자 | 조선기, 조용호, 김석호, 안동준 |
| 소속 | 고려대 |
| 키워드 | 재료(Materials) |
| 원문파일 | 초록 보기 |
