| 초록 |
In this study we developed nanoliposome (DCPmod-NL) system which surface was modified with dicetylphosphate (DCP) to enhance the skin permeation of β-sitosterol. The morphology of DCPmod-NL was observed using TEM and particle size, zeta-potential and encapsulation efficiency(%) were measured. The skin permeation and hydrolysis property within skin was evaluated. The particle size, zeta-potential and encapsulation efficiency values were 119.3±2.03 nm, –29.62±5.45 mV, and over 99%. In addition, we found that the skin permeation was increased when DCP was used. The skin permeation of DCPmod-NL was 19.1, 4.1 and 2.1-fold enhanced (p＜0.001) than that of oil, cream and conventional liposome formulation, which showed the potentials of DCPmod-NL formulation in pharmceuticals and/or cosmeceuticals delivery. |
