| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
A Reduction and pH dual-responsive biodegradable polypeptide micelles for effective treatment of liver cancer |
| 초록 |
A series of pH and reduction biodegradable polypeptide micelles were developed based on disulfide-linked methoxy poly(ethylene glycol) -b-poly(benzyl-L-glutamate) -co-poly[2-(dibutylamino)ethyl-L-glutamate](mPEG-SS-PDAELG) copolymer and applied to act as efficient intelligent carriers to rapid trigger intracellular release of doxorubicin (DOX). mPEG-SS-PDAELG was synthesized by a combination of ring-opening and aminolysis reaction. The pH/reduction-responsive behavior of mPEG-SS-PDAELG was investigated by both dynamic light scattering and fluorescence microscopy. The micelles morphology was confirmed by TEM. The in vitro release studies showed that the DOX-loaded micelles showed retarded drug release at tumor extracellular pH but accelerated drug release at weakly acidic or reductive environment. Our findings suggest that pH/reduction-responsive DOX-loaded micelles selected as a model drug to effective treatment liver cancer. |
| 저자 |
홍 위, 이두성
|
| 소속 |
성균관대 |
| 키워드 |
pH and reduction dual-responsive; biodegradable; polypeptide
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| E-Mail |
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