| 학회 |
한국화학공학회 |
| 학술대회 |
2006년 가을 (10/27 ~ 10/28, 고려대학교) |
| 권호 |
12권 2호, p.1349 |
| 발표분야 |
고분자 |
| 제목 |
Novel pH-responsive Polymeric Micelles: In vitro Experimentation of Various Anti-Cancer Drug |
| 초록 |
In Drug Delivery System, polymeric micelles composed of pH-responsive block copolymers can strengthen the anti-cancer efficiency of a drug by storing in the target area. We synthesized methoxy poly(ethylene glycol)-poly(ß-amino esters) block copolymers with different molar ratios and various bisacrylate ester by Michael type step polymerization. Anti-cancer drug having weak acid (chlorambucil and 5-fluorouracil), weak base (doxorubicin) and hydrophobic (Paclitaxel) were used. The High Performance Liquid Chromatography (HPLC) was used to measure a drug concentration. The in vitro drug release properties were performed a dialysis membrane in PBS buffer solution. The drug-loaded micelles to PBS medium exhibited the pH dependent release behavior. |
| 저자 |
한종권, 김민상, 이두성
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| 소속 |
성균관대 |
| 키워드 |
polymeric micelle; pH-responsive; anti-cancer drug
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| E-Mail |
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| 원문파일 |
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