화학공학소재연구정보센터
학회 한국공업화학회
학술대회 2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU))
권호 23권 2호
발표분야 포스터_생체재료
제목 Cervical Cancer-targeted Photodynamic-cold Atmospheric Dual Therapy by Excess ROS Generation
초록 Photodynamic therapy (PDT) has emerged as an innovative therapeutic method for treating various oncological diseases, including cervical cancer. PDT can convert oxygen into reactive oxygen species (ROS) to suppress tumor growth by using photosensitizer under laser irradiation. Generated ROS can cause significant toxicity leading to cell death via apoptosis. In this study, we report herein on the systhesis of hydrophilic polymeric nanoparticles (PPHE) consisted of Pheo a, γ-polyglutamic acid, amphiphilic Poly(L-lactide–co-glycolide)–poly(ethylene glycol) (PLGA–mPEG), hyaluronic acid and HPV16 E7 analogues (PEG2-TLGIVCPI). In addition, cold atmospheric plasma (CAP) was applied to the cervical cancer therapy to improve therapeutic efficacy. Finally produced PPHE can lead to high cancer cell death rate through PDT and CAP combination therapies.
저자 하지희, 김영진
소속 대구가톨릭대
키워드 Photodynamic therapy; Cold atmospheric therapy; ROS; HPV E7 analogues
E-Mail yjkim@cu.ac.kr