| 초록 |
Non-invasive treatment modalities such as photodynamic therapy (PDT) which is a near-infrared (NIR) responsive nanoplatfrom is extensively studied for the treatment of cancer in recent years. Lanthanide-doped upconversion nanoparticles (UCNPs) that absorb NIR light and emit visible and UV light can generate reactive oxygen species (ROS) by activating adjacent photosensitizer (PS), thus have been used as novel nanomaterials for PDT. In this study, several multi-shell structured UCNPs were prepared by thermal decomposition method. The surface modification of UCNPs was conducted for bioimaging and PDT applications. In addition, PDT effects of the UCNPs-based nanoplatform were investigated using two types of cancer cell lines. |
