| 학회 | 한국공업화학회 |
| 학술대회 | 2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 | 20권 2호 |
| 발표분야 | 정밀화학_포스터 |
| 제목 | Indium(III)-Catalyzed Benzannulation for 2-Hydroxybenzophenones and Their Application as Sun-protecting Materials |
| 초록 | Benzophenones are present in an abundance of biologically active natural products and pharmaceuticals.1 In addition, they have been widely used as active ingredients in sun-protection products.2 Herein, we present an efficient and highly regioselective synthesis of diverse and functionalized 2-hydroxybenzophenone derivatives with excellent yield via the indium(III)-catalyzed reaction of 3-formylchromones or elcetron-deficient chromone-fused dienes with β-enamino esters or β-enamino ketones.3 This reaction proceeds via a domino Michael/retro-Michael/Diels-Alder/deformylation reaction. The synthesized compounds were furthermore screened as important lead compounds for the discovery of new sun-protection materials. 1. Wu, S. B.; Long, C.; Kennelly, E. J. Nat. Prod. Rep. 2014, 31, 1158. 2. Klimová, Z.; Hojerová, J.; Beranková, M. Food Chem. Toxicol. 2015, 83, 237–250. 3. Cai, H.; Xia, L.; Lee, Y. R. Chem. Comm. 2016, 52, 7661. |
| 저자 | 채홍운, 이용록 |
| 소속 | 영남대 |
| 키워드 | benzophenones; domino reaction |
