| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 가을 (11/08 ~ 11/10, 부산 벡스코(BEXCO)) |
| 권호 |
21권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Development of Tri-Functional Nanoparticle with SERS-Magnetic-Fluorescence and their Bioapplications |
| 초록 |
In this study, we synthesized tri-functional NPs (MF-SERS Dots) composed of clustered Fe3O4 NPs at core part, assembled Ag NPs, and a silica shell layer containing fluorescent dye. The SERS signals from the synthesized NPs were strong enough to be detected from even single asymmetric aromatic molecule, and the NPs exhibited fluorescence. In addition, the characteristics of each modality of the MF-SERS Dots were preserved after cellular uptake. Moreover, the MF-SERS Dots could be modified with the CD44 antibody via an amide coupling reaction, and successfully targeted the CD44-positive cells. The tri-functional NPs having SERS, magnetic and fluorescent properties are expected to be useful to nanoprobes for cell separation and multiplexed detection. It is expected that the nanoprobe will be useful for rapid scanning, sensitive detection and separation in bioapplications. |
| 저자 |
김형모1, 김동민1, 차명근2, 하유나1, 김태한1, 함은일1, 강은지1, 정대홍2, 김동은1, 전봉현1
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| 소속 |
1건국대, 2서울대 |
| 키워드 |
SERS; Fluorescence probe; Superparamagnetism; Nanoprobe; Cell separation
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| E-Mail |
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