| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 봄 (04/29 ~ 05/01, BEXCO (부산)) |
| 권호 |
19권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Thermo-responsive nanoparticle-mediated delivery of retinoic acid into human induced pluripotent stem cells for enhanced neuronal differentiation |
| 초록 |
Neuronal differentiation of human induced pluripotent stem cells (hiPSCs) has been studied for application to diverse neurodegenerative diseases. Retinoic acid (RA) is a transcriptional factor known to enhance neuronal differentiation of neural stem cells or progenitor cells. In this study, we report thermo-responsive poly(N-isopropylacrylamide-co-acrylamide) (PNIPAM-co-Am) nanoparticles to efficiently deliver RA into hiPSCs for neuronal differentiation. The synthesized PNIPAM-co-Am nanoparticles exhibited the change of nanoparticle size depending on incubation temperature. The PNIPAM-co-AM nanoparticles incorporated with RA were efficiently transferred into hiPSCs and significantly promoted neuronal differentiation of hiPSCs. In conclusion, thermos-responsive nanoparticles developed in this study could be useful for improving therapeutic efficacy of hiPSCs. Acknowledgment: This work was supported by a grant (HI14C1588) from the Korea Health Technology R&D Project funded by the Ministry of Health and Welfare. |
| 저자 |
조안나1, 서혜인2, 장지호1, 김동욱1, 정봉근2, 조승우1
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| 소속 |
1연세대, 2서강대 |
| 키워드 |
Thermo-responsive nanoparticle; human induced pluripotent stem cell; neuronal differentiation; retinoic acid
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| E-Mail |
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