| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.464 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | The release of albumin from implantable wafers |
| 초록 | It has become important to target research in order to develop the sustained and controlled delivery systems for peptides or proteins. Implantable wafer for drug delivery using the biodegradable synthetic polymers has been widely investigated over the past several years because it has been considered as one of the most convenient methods to capture drug inside administration forms. We here describe the approach to evaluate the release behaviors of bovine serum albumin (BSA) from the implantable wafers prepared by MPEG-PCL diblock copolymers with different compositions. Figure 1 shows releasing profiles of BSA from the wafers. As relative MPEG segment increased or relative PCL segment in diblock copolymers decreased, the release amount of BSA increased. The wafers exhibited the controlled release profiles with a dependence on changing of MPEG-PCL diblock copolymer compositions, even though they had initial burst. Figure 1. BSA amount released from wafers prepared by diblock copolymers. In conclusion, we confirmed the possibility of MPEG-Polyester diblock copolymers as protein carriers for implantable wafer possessing many advantages such as simple manufacture, long-term delivery, and controlled release. |
| 저자 | 조영호1, 서광수1, 정성찬2, 김문석3, 조선행3, 강길선1, 이해방3 |
| 소속 | 1전북대, 2부경대, 3한국화학(연) |
| 키워드 | ultrasonic atomizer; PLGA |
