| 초록 |
Alginate, a polyelectrolyte with many characteristics such as biological origin, biodegradability, and biocompatibility, has been widely used as an attractive natural resource in biomedical applications such as wound dressing. In this study, we prepared a hybrid solution of sodium alginate and silver nanoparticles (AgNP) to produce insoluble calcium alginate for the application as a wound dressing material with antimicrobial activity. The characteristics of products were examined by scanning electron microscopy (SEM), transmission electron microscopy, UV-VIS spectroscopy, X-ray diffraction (XRD), and light scattering for a particle size analysis. The hydrodynamic size of AgNP was controlled by alginate and Ag concentrations. The presence of silver in the alginate-silver hybrids were confirmed by XRD, TEM, and SEM. The alginate-silver hybrids had balanced antimicrobial activity and cytotoxicity, which may be due to a sustained release effect of Ag from the matrix. |
