| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.450 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Synthesis of biodegradable polymeric micelles and determination of the critical micelle concentration |
| 초록 | In this study, we deal with the possibility as novel drug carrier of polysuccinimide with various functional groups such as hydrophilic branch; PEG2,000, PEG5,000, PEG10,000, and hydrophobic branch; octylamine (C8), tetradecylamine (C14), hexadecylamine (C16) and dioctadecylamine (C18). At first, PSI was synthesized by polycondensation polymerization of aspartic acid. Functionalization of PSI was carried out by introduction of PEG2,000, PEG5,000, PEG10,000,, C8, C14, C16, C18. All materials were characterized by 1H-NMR and DLS, Fluorescence spectro photometer. To confirm the formation of micelles, functionalized PSI was diluted in pyrene solution. The critical micelle concentrations (CMC) of functionalized PSI were decreased as molecular weight of PEG decreased. The particle sizes of micelles increased as the hydrophobic property of functionalized PSI increased. In conclusion, we could control CMC of biodegradable polymeric micelle. Fig. 1. Fluorescence excitation spectra of nanoparticles in distilled water (a) Comparison with PEG2,ooo and PEG5,000 (b) Comparison with C8, C14. Acknowledgement : This work was supported by KMOCIE(10011394) Reference 1. P.Caliceti, Biochimica et Biophysica Acta, 1528, 177-186 (2001). 2. Y.Hu, Biomaterials, 24, 2495-2404, (2003). |
| 저자 | 서성미1, 임낙현1, 이현숙1, 이봉2, 김문석1, 강길선3, 이해방1, 조선행1 |
| 소속 | 1한국화학(연), 2부경대, 3전북대 |
| 키워드 | polysuccinimide; CMC; micelle; biodegradable |
