| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Synthesis and characterization of bioreducible PEG-PBLA2 miktoarm copolymers for anticancer drug delivery |
| 초록 |
Recently, a phospholipid-mimicking amphiphilic AB2 miktoarm polymers have attracted much attention for their self-assembling nano-structures and potential applications in drug delivery. In this study, a bioreducible AB2 miktoarm copolymers consisting of one hydrophilic poly(ethylene glycol) block and two hydrophobic poly(β-benzyl L-aspartate)blocks. The PEG-PBLA2 miktoarm copolymers could form self-assembled nanoparticles in aqueous media and efficiently encapsulated an anticancer agent, doxorubicin. The dissociation of the nanoparticle structure was effectively induced by the cleavage of the disulfide bonds in response to intracellular reductive conditions, triggering the rapid drug release. The PEG-PBLA2 miktoarm copolymer based nanoparticles can be useful as a promising nanocarrier for anticancer drug delivery, due to high loading efficiency and capacity, non-toxicity, and high anticancer efficacy due to fast intracellular release. |
| 저자 |
허강무1, 강한창2, 이은지1, 이립1, 김유경1, 서진솔1, Zehedian Khatun1, 이영주1
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| 소속 |
1충남대, 2카톨릭대 |
| 키워드 |
miktoarm copolymer; PEG; PBLA; micelles; bioreducible
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| E-Mail |
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