| 초록 |
Orally absorbable gold nanoparticles (AuNP) having cancer ablation therapy is strongly demanded to treat glioblastoma multiforme (GBM). Here, we develop a milk protein lactoferrin-conjugated AuNP for its oral absorption and targeting to the GBM through lactoferrin receptor that is highly expressed in the intestine, blood-brain barrier and GBM. For stability and long circulation of AuNP, glutathione and polyethylene glycol (PEG) is introduced, which is called to Lf-PEG-AuNP. When orally administered to orthotopic GBM-bearing mice, Lf-PEG-AuNP are highly measured in bloodstreams and GBM in the brain. Therefore, orally administered Lf-PEG-AuNP exhibit an outstanding temperature rise in GBM by irradiating laser and significantly reduce tumor volume. Collectively, we suggest that the Lf-PEG-AuNP can fundamentally target GBM in the brain through oral absorption, and that its efficient photothermal therapy is possible. |
