| 초록 |
Biohybridization between cell-polymer becomes common tool to construct artificial organs or its substitute as a long-term prosthesis. There are two kinds of the biohybrid systems. One is to biohybridize the target cell on the biocompatible and non-degradable polymer surface, and the other is to biohybridize the target cell on the biodegradable polymer scaffold. In the latter system, the polymer is totally substituted by the tissue composed of the grown cells. The biological stability of the cells and tissue is much better in the case of the latter system, compared to that of the first system. To enhance the biocompatibility of biomaterials, particularly the blood compatibility, the seeding endothelial cell lining onto the surface of biomaterials is solution. And to use a implantable biomaterial, biomaterials must have the biocompatibility with other cells such as fibroblast, osteoblast. In our studies, biodegradable PU/PEGDA IPNs having the micro-separated structure were successfully synthesized to enhance the blood compatibility and the cell growth in polymer. Therefore, the biohybridzation with endothelial cells and other cells is good solution to enhance the biocompatibility. Using endothelial cell, fibroblast and osteoblast, biocompatibility of PU/PEGDA IPNs was investigated. |
