| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
고분자합성 |
| 제목 |
Design of Water Soluble Paclitaxel Based on Hyperbranched Polyglycidols |
| 초록 |
Current clinical formulation such as paclitaxel (PTXL) contains a 50:50 mixture of Cremophore EL and ethanol to enhance the solubility of PTXL in water. However, a large number of studies have reported various side effects of Cremophore EL such as hypersensitivity, neurotoxicity, and neuropathy. To overcome the serious side effects, chemical conjugates of PTXL and hyperbranched polyglycidols (HBP) were synthesized by utilizing glutaric anhydride as a “bridge” with esterification in dimethyl formamide. A series of HBP-PTXL conjugates (HPCs) with different molecular weight of HBP and different ratio of HBP to PTXL were synthesized and characterized. An intact form of PTXL was regenerated from HPCs at acidic or basic pH condition. Water soluble HPCs exhibit more enhanced cytotoxic effect for cancer cells suggesting that they can be potentially utilized as tumor-specific injection therapeutic agents. |
| 저자 |
황신화1, 김일2, 유성재3
|
| 소속 |
1부산대, 2고분자공학과, 3합성고분자생물접합 하이브리드재료산업단 |
| 키워드 |
Chemical conjugates; Hyperbranched polyglycidols; Paclitaxel; Cancer therapeutic agents
|
| E-Mail |
|
