| 초록 |
In previous researches, extracellular matrices (ECMs) show the important role in cellular functions like proliferation, migration, and differentiation. There are several types of ECMs having fibrous structures including structural proteins, glycosaminoglycans, and proteoglycans. Classically the morphological features of ECMs have been imitated by polymeric nanofibers. However, because the degree of cross-linking of the polymer is inversely proportional to swelling ratio, these nanofibers have limitations to mimic physical properties of ECMs. In this research, we modulated interchain hydrogen bonding of cross-linked polyvinyl alcohol (PVA) chains in electrospun fibers. It was demonstrated that the swelling ratio was dramatically enhanced and clearly controlled. Also it showed not only enhanced transparency but also increased adhesion of fibroblasts to nanofibers. Finally, these hydrogel nanofibers will be a novel platform for three-dimensional cell culture. |
