| 초록 |
This study is a recrystallization experiment of paracetamol. Paracetamol is a kind of pharmaceutical ingredient which inhibits the biosynthesis of prostaglandin, which transmits pain in the human body, and shows the analgesic effect. Many recrystallization studies have been conducted to control particle size and shape in order to have a precise bioavailability to meet the demand as a pharmaceutical ingredient. In this study, recrystallization experiments were carried out using liquid anti-solvent method(LAS). The LAS method is a method of producing particles by adding a liquid anti-solvent, which is an opposite concept to a solvent, to a solution in which a solute is dissolved in order to form a supersaturated state. Water was used as an anti-solvent, and a 90 vol% acetone aqueous solution was used as a solvent. The injection rate, the temperature, the intensity of ultrasonic waves during recrystallization were set as experimental parameters. The results did not show any changes in particular shape and in crystal structures when compared to the raw material. Only the particle size distribution was significantly influenced by the experimental conditions. |
