| 초록 |
Polyamino acids have been typically synthesized using aliphathic primary amines as a initiator (e.g. n-butylamine, n-hexylamine, etc.). However, it is difficult to control of molecular weight of the reaction product because a number of side reaction, resulting in broad molecular weight distribution of products. To reduce this, we used aniline as a initiator which is a primary aromatic amine compound with low basicity and nucleophilicity. Herein, Nε-carbobenzyloxy-L-lysine was polymerized with aniline as a initiator for the synthesis of poly(L-lysine) (AniPLL). We controlled various synthetic conditions such as reaction temperature, monomer/initiator ratio, solvent to sythesize AniPLL with control. The chemical structure of AniPLL was analyzed using FT-IR and 1H-NMR sepctra and its molecular weight and polydispersity index were confirmed by gel permeation chromatogram. Consequently, AniPLL was successfully synthesized by controlled ring-opening polymerization using aniline as a initiator. |
