| 학회 |
한국화학공학회 |
| 학술대회 |
2005년 봄 (04/22 ~ 04/23, 여수대학교) |
| 권호 |
11권 1호, p.42 |
| 발표분야 |
고분자 |
| 제목 |
Bile Acids Modified Chitosan Oligosaccharides for Efficient Gene Delivery |
| 초록 |
To develop efficient gene carrier, chitosan oligosaccharide (COS) were chemically modified with hydrophobic bile acids (BAs) with different hydrophobicities. The physicochemical properties of the hydrophobized COSs (COSBAs) were investigated by using dynamic light scattering. The COSBAs formed nano-sized particles in aqueous milieu by hydrophobic interaction between the BA groups. The COSBA nanoparticles were efficiently condensed the plasmid DNA, and protected the condensed DNA from endonuclease attacks. Furthermore, some COSBA/DNA complexes showed dramatically enhanced gene transfection efficiencies than unmodified COS and control group of PLL, without noticeable cytotoxic effects. Therefore, the COSBAs could be considered as potential candidates for efficient gene carrier. |
| 저자 |
손소희1, 채수영1, 최창용1, 권중근2, 나재운1
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| 소속 |
1순천대, 2조선이공대 생명환경화공과 |
| 키워드 |
chitosan; gene delivery; nanoparticle; bile acid
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| E-Mail |
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| 원문파일 |
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