| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
대학원생 구두발표 |
| 제목 |
Hyaluronic Acid Multilayer Films Capturing Nanocarriersfor Drug Delivery Platforms |
| 초록 |
We demonstrate the biodegradable hyaluronic acid(HA) multilayer films capturing nanocarriers(NC). The electrostatic interaction between polyethylene imine and HA provides the driving force for layer-by-layer assembly and the encapsulation property of HA enables the films to effectively contain NCs in optimized condition. NC amount captured in the multilayer films was controlled by altering the bilayer number of multilayers, chain length and chain number of HA. Prepared films exhibit good biocompatibility, showing gradual degradation in physiological condition. To confirm that this platform would be effective in cardiovascular applications such as stents, we produced bioactive HA platform capturing pacitaxel NCs. This platform was shown to successfully prevent the proliferation of vascular smooth muscle cells. The results demonstrated represent the facile incorporation and controlled release of various active drugs, leading to useful platforms such as biocompatible implantations. |
| 저자 |
박새봄1, 나완근2, 서진화3, 방석호3, 김병수1, 차국헌2
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| 소속 |
1지능형 유도조합체 연구단, 2화학생물공학부, 3서울대 |
| 키워드 |
hyaluronic acid; multilayer
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| E-Mail |
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