| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 | 29권 1호, p.184 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation of Liposome with Targeting Moiety for the Cancer Cell |
| 초록 | With recent advances in drug delivery, there has been an increasing demand for development of new drug carriers that modified with biological molecules such as specific ligand and growth factor to target specific cells like cancer cells. Therefore, a liposome with EGF was designed to target EGF-R overexpressed on the surface of cancer cells. We prepared a biotinylated liposome using biotinylated phospholipid to evaluate cell targetability and EGF medicated liposome. Particle size of liposomes with targeting moiety was around 200 nm. Biotinylated liposome showed high binding affinity for avidin-FITC. In addition, there was virtually cellular uptake of avidin-biotinylated liposome. Liposome with EGF exhibited similar cell proliferation and viability when compared with control in MTT assay. Acknowledgement: This work was supported by KK-0302-BO. |
| 저자 | 김문석1, 장지욱1, 서광수2, 서동환3, 강길선2, 신병철1, 조선행1, 이해방1 |
| 소속 | 1한국화학(연), 2전북대, 3성균관대 제약학과 |
| 키워드 | liposome; biotin; EGF; targeting; cell viability |
