| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 봄 (04/29 ~ 05/01, BEXCO (부산)) |
| 권호 |
19권 1호 |
| 발표분야 |
나노_포스터 |
| 제목 |
CpG-Loaded Micelles Activate Spleen Dendritic Cell |
| 초록 |
We introduce a versatile carrier system based on DNA nanoparticles (NPs). Incorporation of lipid-modified nucleobases to DNA strands enables formation of micelles in uniform size. In a single self-assembly step the micelles can be equipped with immune adjuvant (CpG) and fluorescent probe through Watson-Crick base-pairing. With the NPs we have investigated effect of the CpG concentration in immunostimulation. We observed dose dependent activation of TLR-9 resulting in DC maturation in vivo. |
| 저자 |
박해인, Andry Ongko Wijoyo, 곽민석
|
| 소속 |
부경대 |
| 키워드 |
DNA; micelle; nanoparticle; immunity
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| E-Mail |
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