| 학회 |
한국화학공학회 |
| 학술대회 |
2009년 봄 (04/23 ~ 04/24, 광주 김대중컨벤션센터) |
| 권호 |
15권 1호, p.376 |
| 발표분야 |
생물화공 |
| 제목 |
Dynamic Control Analysis of the Central Carbon Metabolism of Escherichia coli |
| 초록 |
Central carbon metabolic pathway is the most important among metabolic pathways in all microorganisms because it produces energy and precursors for biosynthesis. In this research, dynamic model for central carbon metabolism of Escherichia coli (E. coli) was constructed by combining phosphotransferase (PTS) system, glycolysis, pentose-phosphate pathway (PPP), and storage material. The mathematical model and parameters in enzyme kinetic equations are based on the information from published literatures. Through dynamic metabolic control analysis (MCA), the key parameters and enzyme kinetics which affect productivity of desired metabolites most were found, and the tendency of the metabolic fluxes at branch points was investigated. |
| 저자 |
원왕연1, 박창훈1, 이상엽2, 이광순1, 이진원1
|
| 소속 |
1서강대, 2한국과학기술원 |
| 키워드 |
metabolic control analysis; metabolic sensitivity analysis; escherichia coli; central metabolism
|
| E-Mail |
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| 원문파일 |
초록 보기 |
