| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 가을 (11/04 ~ 11/06, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
19권 2호 |
| 발표분야 |
나노_포스터 |
| 제목 |
Fabrication of multidimensional conducting polymer nanotubes for highly sensitive and selective field-effect transistor-type carcinoembryonic antigen biosensor applications |
| 초록 |
In this work, highly sensitive and selective FET biosensors were fabricated to detect CEA, using aptamer-fnctionalized multidimensional conducting-polymer (3-carboxylate polypyrrole) nanotubes (Apt–C–PPy MNTs). The C–PPy MNTs are integrated with the CEA-binding aptamer immobilized on the interdigitated array electorde substrate by covalent bonding with amide groups to produce a FET-type biosensor transducer. The resulting C–PPy MNT-based FET sensors exhibit a rapid response in real time (＜1 s), ultrasensitivity toward CEA with a limit of detection of 1 fg mL–1. This limit of detection is 2–3 orders of magnitude more sensitive than previous reports. The liquid-gated FET-type sensor showed specificity toward CEA in a mixed solution containing compounds found in the similar proteins and biological signals. |
| 저자 |
장정식, 박진욱, 안지현
|
| 소속 |
서울대 |
| 키워드 |
polypyrrole; biosensor; field-effect transistor
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| E-Mail |
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