| 초록 |
We have designed reactive oxygen species (ROS) responsive nanoparticles (NPs) for photodynamic therapy (PDT) by conjugating glycol chitosan and pheophorbide A with ROS responsive thioketal linker (GC-TK-PhoeA). In aqueous solution, the amphiphilic GC-TK-PheoA conjugates self-aggregated to form core-shell structured NPs through the hydrophobic interaction of PheoA. The resulting GC-TK-PheoA NPs possessed good colloidal stability and switchable photoactivity. The photoactivity of GC-TK-PheoA NPs in an aqueous environment was greatly suppressed by the self-quenching effect, which enabled the GC-TK-PheoA NPs to remain photo-inactive and in a quenched state. However, the nanoparticular structure instantaneously dissociated in the presence of ROS, followed by an efficient dequenching process. These results suggest that GC-TK-PheoA NPs have good potential as a PDT nanoparticular system for anti-cancer therapy. |
