| 초록 |
Owing to the outstanding progress in the nano-medicine field, a variety of nano-carriers have been designed to specifically deliver the cargo to the target site, in response to the specific stimuli. In this study, we are proposing CD44 targeted IR-780 loaded HA-C18 micelles, which can produce ablation temperature upon laser irradiation. Upon irradiation of the tumor site by laser, tumor cells in the area of illumination would be killed by the heat produced by the NIR dye loaded CD 44 targeted micelles and subsequently reduced the tumor burden. Furthermore, we designed a stimuli responsive, cationic charged micelle as a drug carrier for treatment of peritoneal metastasis. In vivo studies showed enhanced retention efficient inhibition of tumor nodes with no systemic toxicity. Taken together, design of nano carriers responding to exogenous or endogenous stimuli represents an attractive option for triggering the on-demand drug release and thereby enhancing the therapeutic efficacy. |
