초록 |
Electrospinning has recently emerged as a leading technique for generating biomimetic scaffolds for tissue engineering applications. Among the biodegradable polymers, poly(L-lactic acid) (PLA), poly(glycolic acid) (PGA), and their copolymers have been extending their applications to surgical sutures, implant materials, drug carriers, and scaffolds for tissue engineering, because they have a diverse biodegradability, good mechanical property, and biocompatibility. In this study, electrospinning of poly(glycolide-co-lactide) (PGLA) (90 : 10) in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) was investigated for tissue engineering. The structure of PGLA nanofiber webs were characterized by SEM, image analyzer and porosimeter. The cytotoxicity and biocompatibility of the nanofiber webs were also measured by WST-1 and microscopes. The average fiber diameter (690 nm) and pore size (7~12 um) of PGLA nanofiber webs, obtained by electrospinning a 10 wt% PGLA solution in HFIP. |