화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터)
권호 34권 1호
발표분야 의료용 고분자 부문위원회
제목 Structure Control of Electrospun Poly(glycolide-co-lactide)(90 : 10) Nanofiber Webs and Their Potential as Scaffolds in Tissue Engineering
초록 Electrospinning has recently emerged as a leading technique for generating biomimetic scaffolds for tissue engineering applications. Among the biodegradable polymers, poly(L-lactic acid) (PLA), poly(glycolic acid) (PGA), and their copolymers have been extending their applications to surgical sutures, implant materials, drug carriers, and scaffolds for tissue engineering, because they have a diverse biodegradability, good mechanical property, and biocompatibility. In this study, electrospinning of poly(glycolide-co-lactide) (PGLA) (90 : 10) in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) was investigated for tissue engineering. The structure of PGLA nanofiber webs were characterized by SEM, image analyzer and porosimeter. The cytotoxicity and biocompatibility of the nanofiber webs were also measured by WST-1 and microscopes. The average fiber diameter (690 nm) and pore size (7~12 um) of PGLA nanofiber webs, obtained by electrospinning a 10 wt% PGLA solution in HFIP.
저자 이경우, 고재훈, 박영환
소속 한국생산기술(연)
키워드 PGLA; elctrospinning; scaffolds; tissue engineering
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