| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Anisotropy and Mechanical Gradient are Decisive to Segregated Cell Growth: Arena-Shaped Alginate Hydrogel |
| 초록 |
Although alginate is popular for tissue engineering due to its non-cytotoxicity and ease to metal coordination, it is necessary to consider whether alginate can effectively trigger cell adhesion and growth. Unfortunately, cells wouldn't adhere to alginate without conjugating RGD peptide. In present work, alginate chains were manipulated by hydrodynamic flow that occurs inside of the solution when solvent evaporates. Particularly, alginate solution was suitably evaporated and Ca2+ cross-linked in cylindrical compartment. At that time, hydrogel was arena-shaped and elicited birefringence only at the edge of the gel. Furthermore, fibroblast cells on the gel showed circumferential alignment after 168 h only at the edge. It is presumably due to chain organization of alginate and resultant mechanical gradient that was driven from edge-directional flow. Consequently, we suggested that cell’s fate can be altered by manipulating the chain arrangement even for non-preferred substrate. |
| 저자 |
최승환1, Shahrouz Amini2, Ali Miserez2, 김진영3, 원병묵3, 박순모4, 윤동기4, 황동수1
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| 소속 |
1포항공과대, 2Nanyang Technological Univ., 3성균관대, 4Korea Advanced Institute of Science and Technology |
| 키워드 |
alginate; mechanosensing; hydrogel; cell alignmnet; self-assembly
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| E-Mail |
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