| 초록 |
Mesoporous silica nanoparticles (MSNs) have the beneficial physical and chemical properties including the large surface area, uniformly controllable pore sizes, and easy-modifiable surface functionality, which make MSNs nominated as nanocarriers for drug delivery system. Many other nanocarriers such as polymeric nanoparticles and liposomes faced undesirable leakages their cargos from the carriers. However, MSNs have switchable pores, which can be capped to inhibit the undesired leakages and deliver the cargos precisely. Herein we applied several capping agents to control the drug release behaviors. Physical properties including diameter, pore size, and morphology of the different MSN derivatives, capped with amine functional group, gold nanoparticles or proteins, were characterized. Using the modified MSNs, we systemically monitored differential drug release profile in acidic condition compared with neutral environment. Furthermore, Raman spectroscopy was performed to monitor the in situ drug release behavior. We anticipate that these results would be effectively applied to in vivo system for releasing the cargos at abnormal sites. |
