| 학회 |
한국화학공학회 |
| 학술대회 |
2015년 가을 (10/21 ~ 10/23, 일산 KINTEX) |
| 권호 |
21권 2호, p.1764 |
| 발표분야 |
생물화공 |
| 제목 |
Highly Sensitive Immunosensor for Electrical Detection of HIV-1 Pseudovirus Based on Scanning Tunneling Microscopy |
| 초록 |
HIV-1 pseudovirus for highly sensitive immunosensor is crucial because HIV-1 pseudovirus is an important challenging marker to detect for early and rapid diagnosis of acquired immune deficiency syndrome (AIDS). A highly sensitive immunosensor based on scanning tunneling microscopy (STM) was developed for the first time to detect living material such as HIV-1 virus by Au nanoparticle and half antibody hybrid complex. The developed surface morphology and the current profile of fabricated immunosensing element were characterized by Raman spectroscopy and investigated with STM to detect antigen-antibody binding events. Using the electrical detection system based on current mapping profile of STM, living material such as virus, HIV-1 pseudovirus, was able to be detected successfully. The proposed technique can be used to easily construct a multiple measurement system in a protein chip and a promising method to construct the highly sensitive and efficient sensor for detecting viruses and other living materials. Acknowledgment: This work was supported by Samsung Research Funding Center of Samsung Electronics under Project Number SRFC-MA1401-04. |
| 저자 |
최정우1, 오병근1, 김병찬2, 이진호1, 김상욱1
|
| 소속 |
1서강대, 2한국과학기술(연) |
| 키워드 |
HIV-1 pseudovirus; scanning tunneling microscopy; Raman spectroscopy; immunosensor
|
| E-Mail |
|
| 원문파일 |
초록 보기 |
