| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Preparation of shell cross-linked Tetronic-tyramine micelles via enzymatic reaction for controlled drug delivery |
| 초록 |
The shell cross-linked (SCL) polymeric micelles have been studied widely as an effective drug carrier for controlled drug delivery. In this study, the SCL Tetronic-Tyramine (Tet-TA) micelles were developed using enzymatic reaction to improve micelle stability and to control the drug release behavior. The SCL micelles were prepared in aqueous solution in the presence of horseradish peroxidase and hydrogen peroxide. The critical micelle concentration of Tet-TA micelles was 0.03 g/l approximately. The size distribution of the SCL micelles was ranged from 20 to 40 nm. The morphologies of the SCL micelles were observed by AFM and TEM. In addition, the cross-linking degree of the SCL micelles was analyzed by DSC through the Tm and Tg value. The drug loading amount and efficiency were 0.038 mg/mg of polymer and 38 wt% respectively. These results demonstrated that the SCL Tet-TA micelles via enzymatic reaction have a potential as a drug carrier for controlled drug delivery. |
| 저자 |
김배영, 박경민, 정윤기, 박기동
|
| 소속 |
아주대 |
| 키워드 |
Shell cross-linked micelle; enzymatic reaction; micelle stability; controlled drug delivery
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| E-Mail |
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