| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
고분자합성 |
| 제목 |
Smart Triblock Copolymer Micelles as an Efficient Theranostic Platform |
| 초록 |
Smart polymeric materials have been used to develop new nanocarriers for targeted theranostic applications because of their biocompatibility, stimuli responsive behavior and convenience of introducing new functionality. These facilitate the formations of micelles with good biocompatibility, encapsulations efficiency and targeted drug release. Poly(N-isopropylacrylamide)30-block-poly(L-Lysine)30-block-poly(Caprolactone)n (p(NIPAM)30-b-p(Lys)30-b-p(CL)n) (n=50, 75, 100, 125) triblock copolymer bio-conjugates containing degradable disulfide linker have been prepared via a combination of RAFT, ROP of α-amino acid NCAs and click chemistry. Doxorubicin (Dox) was successfully encapsulated in the micelles and the controlled release was investigated in different temperatures, pHs and redox conditions. In vitro experiments suggest the newly prepared nanocarriers are demonstrated to be a promising platform for tumor therapy. |
| 저자 |
RIMESH AUGUSTINE1, 김대경2, 김재호2, 김일2
|
| 소속 |
1Pusan National Univ., 2부산대 |
| 키워드 |
polypeptide; drug delivery
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| E-Mail |
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