| 학회 |
한국공업화학회 |
| 학술대회 |
2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
26권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
EnhancedGastrointestinal Photodynamic Therapy by Cancer Targeting-Ligand linked Hydrophilic Photosensitizer |
| 초록 |
PhotodynamicTherapy (PDT) using photosensitizer (PS) and transform near-infrared (NIR) lightis a remarkable treatment for gastrointestinal (GI) cancer because of its localaction and low side effects. However, common PSs have low PDT effect due topoor hydrophilic and targeting ability. To solve these problems, we proposecancer targeting-ligand linked hydrophilic PS (CHPS) which have cancertargeting ligand and hydrophilic region as a linker. In study, we confirmsynthesis of CHPS through agarose gel electrophoresis, MALDI-TOF. We have demonstratedthat CHPS is more effective in PDT than conventional PSs using Ex vivofluorescent images and TUNEL assay. As a result, we show that CHPS with highwater solubility and cancer targeting ability overcomes traditional PSslimitations and improved therapeutic effects. Also, it can show the possibilitynot only to cancer but also to other diseases. |
| 저자 |
최장호1, 김지영1, 박우람1, 김다혜1, 이은성1, 이돈행2, 정석2, 박재명1, 나건1
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| 소속 |
1가톨릭대, 2인하대 |
| 키워드 |
Photodynamic Therapy; Photosensitizer; Gastrointestinal cancer; Ligand
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| E-Mail |
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