| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.266 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Characterization and MRI contrast effect of biocompatible polysuccinimide grafted Gd-DTPA |
| 초록 | Polysuccinimide has physico-chemical characteristics for development of macromolecular prodrugs, due to biocompatibility, biodegradability, easy synthesis, low cost and easy functionalization.1-2 We deal with the synthesis of PSI having various functional groups such as poly(ethylene glycol) (PEG), Hexadecylamine (C16) and Gd-DTPA via ring opening of PSI. And the formation of nanoparticle micelle as drug carrier was also examined. PSI was synthesized by polycondensation polymerization of aspartic acid. Functionalization of PSI was carried out by introduction of PEG, C16 and Gd-DTPA into PSI. Micelle size was measured by ELS and AFM. Fig. 1 showed micelle size and shape. Also, we measured MRI.3 Fig 2 show contrast effect of gadolinium phantom. Fig. 1 Micelle shape of PSI-PEG- C16-DTPA-Gd. Fig. 2 Contrast effect of PSI-PEG- C16-DTPA-Gd by MRI Acknowledgement : This work was supported by KMOCIE(10011394). Reference 1. L. Lattuada and G. Lux, Tetrahedro. Letters., 44, 3893 (2003). 2. T. Ouchi, M. Shiratani, M. Jinno, M. Hirao and Y. Ohya, Macromol. Chem., 14, 825 (1993). 3. N. Kramer, A. Berlis, J. Klisch, R. Kubalek, H. Miosczka, and M. Schumacher, Academic. Radiology., 9, S447 (2002). |
| 저자 | 임낙현1, 이하영1, 곽병국2, 김문석1, 강길선3, 이해방1, 조선행1 |
| 소속 | 1한국화학(연), 2중앙대, 3전북대 |
| 키워드 | polysuccinimide; MRI; contrast agent; gadolinium; micelle |
